Michael Collins wrote the book on Gypsy Jazz Guitar Literally. Master guitar builder and author Michael Collins is one of the few luthiers in North America to.
One on one attention with a trained caregiver who lives in for up to three months to provide assistance and supervision with activities of daily living, homemaking.
Antidepressants Comparison: Effexor vs. Cymbalta
Dosage for Treatment of Major Depressive Disorder. Administer Cymbalta at a total dose of 40 mg/day given as 20 mg twice daily to 60 mg/day given either once daily.
Cymbalta duloxetine vs. Pristiq/Effexor venlafaxine Anti-Depressants.
And we must be both. Care of Creation is an environmental organization formed in 2005 to bring together two important themes: Love for God’s People, and love for God’s world, as we face a rapidly changing global environment. We are also a missions organization because we believe that environmental problems are sin problems, and the global Church of Jesus Christ is the world’s best hope for dealing with this crisis. Simply stated, we believe that missions and care for God’s creation belong together. Our goal is to mobilize the Church to respond to environmental challenges with and through the love of God. In terms of theology we believe that to be truly evangelical – believing that Jesus Christ has come with ‘good news’ for the human race and for all creation – we have to be concerned about the environment. In terms of reality – what is really going on in the world right now – we know that millions of people are suffering from this environmental crisis; we simply cannot love people without caring for God’s creation. We are at work … In Kenya through Care of Creation Kenya (CCK) based at the well-known Moffat Bible College near Kijabe, where we are involved in
What is Cymbalta. Cymbalta is a medication approved by the Food and Drug Administration to treat several different health conditions. It s primarily prescribed to.
SNRIs - new class of antidepressants Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used to treat depression and other affective disorders. SNRIs were developed more recently than SSRIs and currently there are four medications in this class approved by the FDA for use: venlafaxine (brand name: Effexor), duloxetine (brand name Cymbalta), milnacipran (Savella, not approved for major depressive disorder), and desvenlafaxine (Pristiq). These new drugs, because of their specificity for the serotonin and norepinephrine reuptake proteins, lack most of the adverse side effects of tricyclic antidepressants and monoamine oxidase inhibitors. Venlafaxine HCl (Effexor, Effexor XR) is the first and most commonly used SNRI. It was introduced by Wyeth in 1994. Duloxetine HCl (Cymbalta), manufactured by Eli Lilly, is a newer antidepressant on the market. It was approved by the FDA and released on the market in August 2004. SNRIs have the ability to affect two neurotransmitters - serotonin and norepinephrine. Clinical studies have shown that the SNRIs are generally quicker acting and more effective in treating severe major depressive disorder, treatment-resistant depression, and depressive symptom remission than SSRI antidepressants5. Currently there is not enough information to firmly recommend one antidepressant over another and selection of antidepressant therapy should be done on an individual basis. Drugs may work differently for different people. What is effective for some may not be effective for others. This article provides some comparative data based on the analysis of medication prescribing information and scientific studies. Mechanism of action When serotonin and noradrenaline are released from nerve cells in the brain they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood. It is thought that when depression occurs, there may be a decreased amount of serotonin and noradrenaline released from nerve cells in the brain. SNRI antidepressants work by preventing serotonin and noradrenaline from being reabsorbed back into the nerve cells in the brain. This helps prolong the "mood lightening" effect of any released serotonin and noradrenaline. In this way SNRIs help relieve depression. It may take between two to four weeks to feel the benefits of these medicines. Venlafaxine (Effexor, Effexor XR) has the flexibility of being an SSRI at lower doses (75 mg/day), affecting the reuptake of serotonin, and an SNRI at higher doses (150-225 mg/day). It also very weakly blocks the reuptake of dopamine at very high doses (above 350 mg/day). Duloxetine (Cymbalta) is a strong, balanced inhibitor of both norepinephrine and serotonin reuptake. Duloxetine differs from venlafaxine in that it is comparatively more noradrenergic. Venlafaxine has a 30-fold higher affinity for serotonin than for norepinephrine while duloxetine has a 10-fold selectivity for serotonin6. Approximate potency ratios (5-HT:NE) are 1:10 for duloxetine, and 1:30 for venlafaxine. The extended-release formulation of Effexor has been approved for the treatment of panic disorder and social anxiety disorder, these are not labeled indications for Cymbalta. FDA approved Cymbalta for the management of neuropathic pain associated with diabetic peripheral neuropathy and fibromyalgia. However, these are not labeled indications for Effexor. Duloxetine is also being evaluated in the treatment of stress urinary incontinence (officially approved in Europe for this problem). Effectiveness Depression Both antidepressants have similar effectiveness in the treatment of depression 1, 17. One randomized, double-blind study compared Cymbalta (duloxetine) 60 mg/day and Effexor XR (extended-release venlafaxine) 150 mg/day in the treatment of major depressive disorder1. Both Cymbalta and Effexor XR demonstrated substantial antidepressant efficacy as measured by the HAMD 17 total score. Many doctors favour duloxetine over venlafaxine when pain conditions coexist with depression 15. Anxiety disorder Duloxetine is just as effective as venlafaxine in the treatment of generalized anxiety disorder (GAD)2. Off-label (investigational) uses Many doctors are starting to prescribe venlafaxine (Effexor) "off-label" for the treatment of diabetic neuropathy (in a similar manner to Cymbalta) and migraine prophylaxis (in some people, however, venlafaxine can exacerbate or cause migraines). Studies have shown Effexor effectiveness for these conditions. It has also been found to reduce the severity of 'hot-flashes' in menopausal women. Effexor is also prescribed for off-label uses such as chronic fatigue syndrome, and obsessive-compulsive disorder (OCD). At present, Cymbalta is not approved for treating bipolar depression, but is being prescribed to people with bipolar disorder as an off-label use. Patients who have experienced mania should be monitored carefully when taking this medication. There are more controlled studies with duloxetine (Cymbalta) showing benefit for all kinds of pain than any other antidepressant. In clinical trials, Cymbalta 60 mg once daily demonstrated efficacy in painful physical symptoms associated with depression. Cymbalta is being studied for the treatment of stress urinary incontinence, which may also respond to treatment with both serotonin and norepinephrine. Side effects and toxicity Nausea is the most frequent side effect with SNRIs, and may cause some people to stop treatment. The extended-release formulation of venlafaxine is less likely to cause nausea than the regular tablet. Cymbalta is more likely cause nausea than Effexor XR1. The most common side effects: Hepatotoxicity Serious and potentially fatal hepatotoxicity has been reported with duloxetine. Postmarketing reports have described isolated cases of liver failure, including fatalities, which were possibly related to duloxetine. Most cases were in people with past or current risk factors for liver injury, including alcohol abuse. Duloxetine should not be used in patients with any hepatic function impairment and should not be taken by heavy drinkers. Unlike duloxetine, venlafaxine is not expected to exert additive hepatotoxic effects in patients susceptible to liver damage. Increased blood pressure Both duloxetine (Cymbalta) and venlafaxine (Effexor) can cause increases in blood pressure. The risk of treatment-emergent blood pressure elevations appear to be greater for venlafaxine than with duloxetine1. Venlafaxine can cause both transient and sustained elevations of diastolic blood pressure and regular monitoring of blood pressure throughout venlafaxine therapy is recommended in the prescribing information. Venlafaxine has a dose-dependent effect on diastolic blood pressure, but clinically significant hypertension is only induced at doses >300 mg/day7. In studies, duloxetine was shown to slightly increase blood pressure, but this drug does not appear to be associated with sustained hypertension8. Duloxetine (Cymbalta) may be the preferred agent for patients with elevated blood pressure. Mydriasis Duloxetine (Cymbalta) and venlafaxine (Effexor) can cause mydriasis (excessive dilation of the pupil), and patients with increased intraocular pressure or those at risk of acute narrow-angle glaucoma should use these medications with caution. The use of Cymbalta is contraindicated in patients with uncontrolled narrow-angle glaucoma. Sexual side effects Sexual side effects include decreased libido, anorgasmia and erectile dysfunction. Duloxetine seems less likely to produce sexual dysfunction than venlafaxine9. Anticholinergic effects Drugs that antagonize the muscarinic receptor cause anticholinergic side effects, such as dry mouth, constipation, blurred vision and urinary retention. Duloxetine (Cymbalta) has a higher affinity for this type of receptor than venlafaxine (Effexor), which accounts for the somewhat higher rate of dry mouth, constipation, and blurred vision with duloxetine than with venlafaxine. Insomnia Both duloxetine and venlafaxine are reported to cause insomnia, probably because of the increase in NE levels. The percentage of patients who experience insomnia increases with higher doses. About 10-16% of patients taking duloxetine and 16-24% of those taking venlafaxine experience insomnia. Cardiovascular effects Duloxetine is associated with a small increase in heart rate8. Duloxetine can cause tachycardia, even in low doses10. Venlafaxine can cause cardiovascular side effects11. Fatalities have been reported in patients taking overdoses of venlafaxine, predominantly in combination with alcohol or other drugs. This drug may cause mean increase in heart rate of 4-9 beats/minute. Tolerability Tolerability of SNRI antidepressants varies within the class. Venlafaxine (Effexor) may be better tolerated than duloxetine (Cymbalta) in the initial period of treatment. In clinical trials, duloxetine 60 mg daily caused more discontinuations due to side effects than venlafaxine 150 mg daily1,2. The most common events leading to discontinuation of Effexor XR are: nausea, dizziness, somnolence, insomnia, dry mouth. The most common reasons leading to discontinuation of Cymbalta are: nausea, dizziness, somnolence. Withdrawal symptoms As with SSRIs, the abrupt discontinuation of an SNRI usually leads to withdrawal, or "discontinuation syndrome". Withdrawal symptoms may occur on stopping, missing doses or, reducing the dose of the drug. Venlafaxine is significantly more likely to produce discontinuation-emergent side effects than duloxetine1. This is likely due to venlafaxine's relatively short half-life and therefore rapid clearance upon discontinuation. Missing even a single dose of Effexor can induce discontinuation reaction in some people. Headache, nausea, fatigue, dizziness, irritability, insomnia and dysphoria are most frequent withdrawal symptoms, and may make cessation of the drug extremely difficult12. Common withdrawal difficulties following discontinuation of duloxetine are dizziness, nausea, headache, paresthesia, vomiting, irritability, and nightmares13. Drug interactions Venlafaxine (Effexor) is less likely than duloxetine (Cymbalta) to interact with co-administered medications4. Unlike venlafaxine, duloxetine is highly protein bound in human plasma. Two highly protein-bound drugs can compete with each other for binding sites and one drug can displace the other from the binding sites. This would lead to higher levels of unbound drug leading to both enhanced pharmacological effect and toxicity. Although there are compensatory mechanisms in the body to buffer against such events, there has been a case report citing such an interaction involving duloxetine and warfarin14. Such interactions are not expected with venlafaxine due to its low protein-binding properties. Venlafaxine should be used cautiously with drugs that elevate blood pressure because of dose-dependent increases in blood pressure. Duloxetine would be the suitable antidepressant in patients with hypertension. Duloxetine is extensively metabolized by cytochrome P450 isoenzymes CYP 1A2 and CYP 2D6, creating an important risk of interactions with other drugs. For example, the bioavailability of duloxetine is a third less in smokers compared to nonsmokers because of induction of CYP 1A2 metabolism. Venlafaxine does not appear to inhibit CYP isoenzymes to any significant degree. Summary of drug interactions: Venlafaxine (Effexor) Duloxetine (Cymbalta) Inhibitors of CYP 2D6 and CYP 3A4 → increase in venlafaxine levels CYP 2D6 and CYP 1A2 substrates → increase in drug levels Inducers of CYP 2D6 and CYP 3A4 → decrease in venlafaxine levels Inhibitors of CYP 2D6 and CYP 1A2 → increase in duloxetine levels Inducers of CYP 2D6 and CYP 1A2 → decrease in duloxetine level Highly protein-bound drugs → displacement from protein binding leading to toxicity MAOIs → serotonin syndrome + HTN crisis MAOIs → serotonin syndrome + HTN crisis Serotonergic drugs → serotonin syndrome Serotonergic drugs → serotonin syndrome Drugs that increase BP → Additive increase in BP Hepatotoxic drugs → additive hepatotoxicity Drugs that alter EKG → additive cardiac conduction changes Absorption Food does not affect the bioavailability of venlafaxine (Effexor) or its active metabolite, ODV (O-desmethylvenlafaxine). Time of administration (AM vs PM) did not affect the pharmacokinetics of venlafaxine and ODV from the 75 mg Effexor XR capsule. Food does not affect the maximal plasma concentrations of duloxetine (Cymbalta), but delays the time to reach peak concentration by approximately 4 hours (from 6 to 10 hours) and it marginally decreases the extent of absorption by about 10%. There is a 3-hour delay in absorption and a one-third increase in apparent clearance of duloxetine after an evening dose as compared to a morning dose. The bioavailability of duloxetine appears to be reduced by about one-third in smokers. However, dosage modifications are not considered necessary. The bioavailability of venlafaxine is not affected by smoking.
We are evangelical and environmental. And we must be both. Care of Creation is an environmental organization formed in 2005 to bring together two important themes.
SNRIs antidepressants comparison: compare Effexor venlafaxine to Cymbalta duloxetine, mechanism of action, indications, side effects, similarities and differences.
Increasing the Impact of Nonprofits. Collins Group, a division of Campbell Company, guides nonprofits on fundraising and advancement, enabling organizations to.